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KMID : 0923620140140010001
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Immune Network
2014 Volume.14 No. 1 p.1 ~ p.6
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Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice
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Fujiwara Shigeyoshi
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Abstract
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Epstein-Barr virus (EBV) is etiologically associated with a va-riety of diseases including lymphoproliferative diseases, lym-phomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new- world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-asso-ciated diseases, have not been available. Recently the devel-opment of severely immunodeficient mouse strains enabled production of humanized mice in which human immune sys-tem components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author’s group addressing reproduction of EBV infection and pathogenesis in humanized mice.
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KEYWORD
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Epstein-Barr virus, Humanized mouse, Lymphoproliferative disease, Rheumatoid arthritis, Immune response, Persistent infection
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